Research

Equine Metabolic Syndrome (EMS)

Equine Metabolic Syndrome (EMS) is characterized by three main features: obesity or regional adiposity (accumulation of fat in certain areas, particularly the neck), insulin resistance (IR) a “pre-diabetic” like state, and laminitis in horses and ponies. 

Equine Recurrent Uveitis (ERU)

Equine recurrent uveitis (ERU) is the leading cause of equine blindness, resulting from chronic and painful episodes of inflammation in the uveal tract of the eye. A definitive inciting cause for uveitis has not yet been determined; however, the inflammation is widely thought to be due to an immune-mediated reaction in genetically susceptible animals. 

Grey Horse Melanoma

Melanomas are a tumor of the melanocyte, the skin cell that produces pigment which gives the skin and hair its characteristic color. Melanomas are common in aging gray horses, with an incidence of 80% in gray horses older than 15 years old.

Polysaccharide Storage Myopathy (PSSM), Type 1

Polysaccharide Storage Myopathy (PSSM) is an inherited muscle disease that affects many and diverse breeds of horses. The clinical characteristics of PSSM vary between breeds, from muscle pain, cramping and cell damage with exercise, to progressive muscle atrophy. 

Polysaccharide Storage Myopathy (PSSM), Type 2

Our most recent research suggests that there are at least two forms of PSSM: Type 1, which is caused by the GYS1 mutation and Type 2, which is the term we are currently using for the yet to be identified cause of other PSSM cases. These two forms of PSSM are present in varying and largely unknown proportions in each breed of horse.

Recurrent Exertional Rhabdomyolysis (RER)

Equine exertional rhabdomyolysis (ER), often referred to as “tying-up”, is a clinical syndrome characterized by painful muscle contractures with exercise and skeletal muscle fiber necrosis. Thoroughbred horses are particularly susceptible to ER, with 5-10 % of all Thoroughbreds developing ER during a racing season.

Osteochondrosis (OCD)

Osteochondrosis (OC) falls within the constellation of developmental orthopedic disorders and is very common in horses as well as other species. OC is caused by a failure of normal cartilage development at the end of long bones (such as those found in the legs) and vertebrae (in the neck and back).